Oral and Salivary Biomarkers Associated With Stroke

University Hospital Center (CHU) of Constantine, Algeria

Status: Begins enrollment in 1 month

Conditions: Stroke

Study type: Observational

Funder types: Other

Identifiers

NCT07357155

CHU-STROKE-001

Details and patient eligibility

About

This observational study aims to explore the association between oral and salivary biomarkers and stroke. The study will include adult participants diagnosed with stroke and will analyze clinical, oral, and salivary parameters. The objective is to improve understanding of potential links between oral health, salivary biomarkers, and cerebrovascular disease. No experimental intervention will be performed.

Full description

Stroke is a major cause of morbidity and mortality worldwide. Growing scientific evidence suggests that oral health and salivary biomarkers may reflect systemic inflammatory and vascular conditions.

This observational study is designed to evaluate associations between oral clinical findings, salivary biomarkers, and stroke. Participants with a confirmed diagnosis of stroke will be enrolled. Data collection will include demographic information, medical history, oral examination findings, and salivary samples.

Analyses will focus on identifying correlations between oral and salivary parameters and clinical characteristics of stroke. This study does not involve any therapeutic intervention or experimental treatment. The findings may contribute to a better understanding of the oral-systemic relationship in cerebrovascular diseases and support future preventive strategies.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged 18 to 90 years.
• Patients diagnosed with stroke (ischemic or hemorrhagic) confirmed by clinical and imaging criteria for the stroke group.
• Healthy volunteers without a history of stroke or cerebrovascular disease for the control group.
• Ability to provide written informed consent.

Exclusion criteria

• inflammatory disease at the time of sampling.
• Chronic autoimmune or malignant disease.
• Recent major surgery or trauma within the last 3 months.
• Pregnancy or breastfeeding.
• Inability or refusal to provide saliva samples.

Trial design

120 participants in 2 patient groups

Stroke group

Description:

Patients diagnosed with stroke.

Healthy control group

Description:

Healthy participants without a history of stroke.