Oral and Systemic aMMP-8 in Periodontal Disease

Aydin Adnan Menderes University

Status: Completed

Conditions: Periodontal Diseases; Periodontal Inflammation

Treatments: Other: Biochemical analysis

Study type: Observational

Funder types: Other

Identifiers

NCT04268381

20-2T/39

Details and patient eligibility

About

Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health. Matrix metalloproteinase (MMP)-8 is the major collagenase of periodontal tissue breakdown. The aim of the present study is to analyze active (aMMP-8) levels in gingival crevicular fluid (GCF), saliva and serum in the context of new criteria of gingivitis and stage 3 grade C periodontitis.

Enrollment: 83 patients

Sex: All

Ages: 25 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• systemically healthy and non-smoker individuals aged 25 to 50 years
• having ≥20 teeth present (except third molars)
• individuals with periodontally healthy, gingivitis and stage 3 periodontitis diagnoses

Exclusion criteria

• having any systemic disease
• smoking
• pregnancy or lactation
• using antibiotic or any anti-inflammatory drug or any periodontal treatment within the past 6 months.

Trial design

83 participants in 3 patient groups

Healthy (n=23)

Treatment:

Other: Biochemical analysis

Gingivitis (n=20)

Treatment:

Other: Biochemical analysis

Periodontitis (n=40)

Treatment:

Other: Biochemical analysis