Oral Antibiotic Prophylaxis in Colorectal Surgery (ABCR)

University of Leipzig

Status: Unknown

Conditions: Surgical Site Infection; Anastomotic Leak

Treatments: Drug: Paromomycin Sulfate Powder

Study type: Observational

Funder types: Other

Identifiers

NCT03759886

ABCR

Details and patient eligibility

About

The investigators perform a case-control study to compare preparation before elective colorectal surgery. The first group is a prospective patient - registry in all patients with mechanical bowel preparation (MBP) and oral antibiotic prophylaxis the day before colorectal surgery. The second group is a historic collective of patients with MBP only and colorectal surgery. The cases were matches in American Society of Anesthesiologists (ASA) physical status classification system, BMI, operative procedure and risk factors.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all colorectal resections

Exclusion criteria

• allergy

Trial design

100 participants in 2 patient groups

Oral Antibiotics

Description:

The patients get mechanical bowel preparation and oral antibiotic prophylaxis with 4g Paromomycin (Paromomycin Sulfate Powder) and 1 g Metronidazole p.o. and perioperative i.v. antibiotic prophylaxis with Ertepanem 1g i.v.

Treatment:

Drug: Paromomycin Sulfate Powder

iv Antibiotics

Description:

The patients get mechanical bowel preparation and perioperative i.v. antibiotic prophylaxis with Ertepanem 1g i.v.