Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes

VA New York Harbor Healthcare System

Status: Completed

Conditions: Nephrolithiasis

Study type: Observational

Funder types: Other U.S. Federal agency

Identifiers

NCT01300039

573

Details and patient eligibility

About

The investigators are finding out if giving antibiotics for Helicobacter pylori will eliminate colonization of the colon by Oxalobacter formigenes.

Full description

Background and objectives: Oxalobacter formigenes (OF) may play a protective role in preventing calcium oxalate stones. Intestinal colonization by OF is associated with reduced urinary oxalate excretion. Exposure to antibiotics may be an important factor contributing to variable rates of colonization. This is the first prospective study to evaluate the effect of antibiotics on OF colonization.

Design, setting, participants, & measurements: The effect of antibiotics on OF colonization was compared in 2 groups: a group receiving antibiotics for gastric infection with Helicobacter pylori (HP) and a group without HP that not receiving antibiotics. OF colonization in stool was detected by oxalate degradation at baseline and after 1 and 6 months.

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-80 years old
• undergoing upper endoscopy
• H. pylori present or absent on gastric histology
• stool positive for Oxalobacter formigenes

Exclusion criteria

• unable to consent
• stool negative for Oxalobacter formigenes

Trial design

50 participants in 2 patient groups

Antibiotics for H. pylori

Description:

Patients who underwent upper endoscopy and were found to have H. pylori, and were then to be treated with antibiotics for eradication of H. pylori

Control group, no H. pylori

Description:

Patients who underwent upper endoscopy and found to not have H. pylori, and then would not receive antibiotics