Oral Contraceptive Pill and GnRH Antagonist Versus Long Protocol in IVF Patients (Larganta)

IVI Madrid

Status: Completed

Conditions: Infertility

Treatments: Drug: levonorgestrel and ethynilestradiol

Study type: Interventional

Funder types: Other

Identifiers

NCT01157754

MAD-GV-05-2009-01

Details and patient eligibility

About

Recent controversy has arisen regarding the use of the pill for cycle planning in GnRH antagonist IVF cycles. The investigators performed this study to compare such a protocol with the gold-standard still today, which is the long-agonist protocol with no previous use of the pill.

Enrollment: 115 patients

Sex: Female

Ages: 18 to 38 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1st or 2nd IVF cycle
• BMI <30 kg/m2
• regular menstrual cycles
• basal FSH <10 IU and E2 <60 pg/ml

Exclusion criteria

• Polycystic ovaries
• endometriosis
• previous ovarian surgery
• previous low ovarian response

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

115 participants in 2 patient groups

OCP+GnRH antagonist

Experimental group

Description:

Microgynon 14 to 21 tablets starting COH on day 5 post pill, rFSH + GnRH antagonist

Treatment:

Drug: levonorgestrel and ethynilestradiol

long GnRH agonist

Active Comparator group

Description:

daily triptorelin starting day 21st of previous cycle

Treatment:

Drug: levonorgestrel and ethynilestradiol