Oral Contraceptives as Infertility Treatments for Premature Ovarian Failure

N

Navy General Hospital, Beijing

Status

Unknown

Conditions

Menopause, Premature
Primary Ovarian Insufficiency

Treatments

Drug: Drospirenone and ethinyl estradiol combination (Yasmin)

Study type

Interventional

Funder types

Other

Identifiers

NCT02757469
OCPOF-1

Details and patient eligibility

About

Premature ovarian insufficiency (POI) is a life-changing condition that affects women in their reproductive age. There is a lack of reports which focus on how to improve the reproductive outcome of these women who wish to conceive spontaneously or use assisted conception with their own oocytes. However, one could surmise that it is important to lower gonadotropin levels into the physiological range before embarking on any treatment, even if natural conception is the only choice for the woman/couple.

Enrollment

20 estimated patients

Sex

Female

Ages

18 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • premature ovarian failure
  • normal anatomy
  • normal secondary sexual characteristics
  • essential or idiopathic

Exclusion criteria

  • chromosomal disorder
  • iatrogenic injury
  • autoimmune diseases
  • infection
  • genetic diseases

Trial design

Primary purpose

Treatment

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

20 participants in 1 patient group

Yasmin
Experimental group
Description:
Pregnancies will occur while the women are taking oral contraceptives (Yasmin). The possible role of exogenous estrogens in sensitizing the granulosa cells to the effect of follicle-stimulating hormone and thereby inducing ovulation and conception in some women with premature ovarian failure is examined.
Treatment:
Drug: Drospirenone and ethinyl estradiol combination (Yasmin)

Trial contacts and locations

1

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Central trial contact

Yunhai Chuai, Dr

Data sourced from clinicaltrials.gov

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