Oral Curcumin Supplementation in Middle-Aged and Older Adults Improves Vascular Function

University of Colorado Boulder (CU)

Status: Unknown

Conditions: Vascular Aging

Treatments: Drug: Placebo pill; Drug: Low-dose curcumin pill; Drug: High-dose curcumin pill

Study type: Interventional

Funder types: Other

Identifiers

NCT01968564

B6398

Details and patient eligibility

About

The proposed study will assess the ability of curcumin, the active ingredient in the Indian spice tumeric, to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines by establishing a novel, easy to deliver, cost-effective therapy for treating age-associated arterial dysfunction and reducing the risk of cardiovascular disease with age.

Enrollment: 118 patients

Sex: All

Ages: 45 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• women must be postmenopausal
• body mass index (BMI) <40 kg/m2
• weight stable in the prior 3 months
• absence of clinical disease as determined by medical history, physical examination, blood and urine chemistries, ankle-brachial index, and a graded exercise stress test with monitoring of blood pressure and 12-lead ECG

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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118 participants in 3 patient groups, including a placebo group

High-dose curcumin pill

Experimental group

Treatment:

Drug: High-dose curcumin pill

Low-dose curcumin pill

Experimental group

Treatment:

Drug: Low-dose curcumin pill

Placebo pill

Placebo Comparator group

Treatment:

Drug: Placebo pill