Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles

Memorial Sisli Hospital, Istanbul

Status and phase: Unknown; Phase 4

Conditions: Fertilization in Vitro; Reproductive Techniques, Assisted; Progesterone; Dydrogesterone; Embryo Transfer; Infertility, Male; Drug Effect; Infertility, Female

Treatments: Drug: Dydrogesterone 10 MG Oral Tablet; Drug: Progesterone Vaginal Gel [Crinone]

Study type: Interventional

Funder types: Other

Identifiers

NCT04124913

2019/001

Details and patient eligibility

About

The aim of this randomized controlled trial is to compare the efficacy of oral dydrogesterone vs. micronized vaginal progesterone for luteal phase support in frozen-thawed embryo transfer cycles.

Enrollment: 140 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages between 20 and 40
• Modified natural frozen- thawed embryo transfer cycles

Exclusion criteria

• Recurrent implantation failure
• Recurrent pregnancy loss
• Presence of uterine pathology

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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140 participants in 2 patient groups

Dydrogesterone

Experimental group

Treatment:

Drug: Dydrogesterone 10 MG Oral Tablet

Vaginal progesterone

Active Comparator group

Treatment:

Drug: Progesterone Vaginal Gel [Crinone]