Oral Dydrogesterone vs. Vaginal Micronized Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer

Wolfson Medical Center (WMC)

Status: Unknown

Conditions: ART

Treatments: Drug: Endometrin 100Mg Vaginal Insert; Drug: Dydrogesterone 10 MG

Study type: Interventional

Funder types: Other

Identifiers

NCT03832699

0013-19-WOMC

Details and patient eligibility

About

The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.

Full description

Progesteron is used for luteal phase support in IVF cycles. Progesterone can be administered vaginally and orally. Duphaston is an oral progesterone drug, which has recentlly been proven effective in fresh cycle IVF. Yet, less is known regarding its efficacy in frozen cycle IVF. Thus, the objective of our trial is to compare the efficacy of vaginal and oral progesterone in frozen IVF cycles.

Enrollment: 100 estimated patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Ages 18-39
• Modified natural cycle (induction of ovulation with HCG)
• Consent to participation

Exclusion criteria

• None

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Oral progesterone

Experimental group

Treatment:

Drug: Dydrogesterone 10 MG

Vaginal progesterone

Active Comparator group

Treatment:

Drug: Endometrin 100Mg Vaginal Insert