Oral Fluency and the Response to Antidepressant Therapy in the Elderly With a Unipolar Depressive Episode (PREDICTage)

Centre Hospitalier Universitaire de Besancon

Status: Unknown

Conditions: Unipolar Depression

Treatments: Other: Neuropsychological evaluations; Other: Cardiovascular risk assessment; Other: Psychiatric interview

Study type: Interventional

Funder types: Other

Identifiers

NCT03227133

P/2016/297

Details and patient eligibility

About

The study focuses on the identification of clinical, physiological and morphological markers that could predict the response to antidepressant in elderly suffering from unipolar depressive disorder.

Enrollment: 42 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Depressive episode according to DSM-5 criteria
• Unipolar depression
• MADRS ≥ 20
• Antidepressive treatment (Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors)

Exclusion criteria

• Other comorbid mental disorders (bipolar disorder, schizophrenia, recent addiction < 3 months except for tobacco)
• Depression with psychotic features
• Serious unstabilized somatic illness
• Protected persons
• Dementia suspected at the time of enrollment

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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42 participants in 1 patient group

Single arm

Experimental group

Description:

Psychiatric interview, Neuropsychological evaluations, cardiovascular risk assessment

Treatment:

Other: Neuropsychological evaluations

Other: Cardiovascular risk assessment

Other: Psychiatric interview