Oral Glucose Stimulation in Normal-weight and Obese Volunteers

University Hospital Basel

Status: Completed

Conditions: Endocrine System Diseases

Treatments: Dietary Supplement: Glucose 10g; Dietary Supplement: Placebo; Dietary Supplement: Glucose 25g

Study type: Interventional

Funder types: Other

Identifiers

NCT01875575

EKBB 08/11

Details and patient eligibility

About

The objective of this study is to examine gastric emptying and satiety hormones after oral glucose stimulation in 2 different concentrations in normal-weight and obese patients.

Enrollment: 24 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy normal weight subjects with a body-mass index of 19.0-24.5 or healthy obese subjects with a body-mass index of > 30
• Normal eating habits
• Age 18-40 years
• Stable body weight for at least three months

Exclusion criteria

• Smoking
• Substance abuse
• Regular intake of medications (except for oral contraceptives)
• Medical or psychiatric illness
• Any abnormality detected during the screening procedure
• history of gastrointestinal disorders
• food allergies

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

---

24 participants in 3 patient groups, including a placebo group

Glucose 10g

Active Comparator group

Description:

10g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube

Treatment:

Dietary Supplement: Glucose 10g

Glucose 25g

Active Comparator group

Description:

25g Glucose in 200ml tap water given orally (plus 50 mg 13C-sodium acetate)via nasogastric tube

Treatment:

Dietary Supplement: Glucose 25g

Placebo

Placebo Comparator group

Description:

intragastric tap water

Treatment:

Dietary Supplement: Placebo