Oral Health for Healthy Cognitive Aging (SOECS)

University of Granada (UGR)

Status: Active, not recruiting

Conditions: Malocclusion; Dementia

Treatments: Procedure: Orthodontic treatment of malocclusion; Procedure: Dental occlusion restoration

Study type: Interventional

Funder types: Other

Identifiers

NCT02986386

SOECS-905

Details and patient eligibility

About

Oral health is a critical factor of systemic health, although usually forgotten. A potential relation between cognitive deficits and oral diseases has been suggested. Adult cognitive dysfunctions have a high impact, not only economic, but social and in the family environment. Based on anatomical connectivity between the oral cavity and the central nervous system, the proposed study hypothesizes that masticatory function is a relevant determinant of human cognitive health. The restoration of canonical masticatory function and masticatory training could help to delay the development of such conditions. This project will also test if restoring phasic masticatory function improves the execution of cognitive tasks.

Full description

Objective 1: To determine volumetric and anatomical changes of subcortical structures and cortical areas involved in the masticatory circuit and superior cognitive functions.

Objective 2: To determine the functional and brain connectivity changes associated with malocclusion and oral health.

Objective 3: To correlate the anatomic and functional changes associated with malocclusion and oral health with the performance of cognitive tasks representative of those executed in daily life.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• For Dental occlusion restoration groups: Need of, at least, two molar teeth replacement in the same quadrant.
• For Orthodontic treatment of malocclusion groups: Class I, II or III malocclusion.

Exclusion criteria

• Psychoactive drug.
• Central nervous system depressor.
• Patients not willing or not able to consent.

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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150 participants in 4 patient groups

Intervention 1

Experimental group

Description:

Dental occlusion restoration by placement of dental implants and prosthesis on missing teeth.

Treatment:

Procedure: Dental occlusion restoration

Wait list control 1

Other group

Description:

Group of patients that will be evaluated until they receive the dental occlusion restoration procedure.

Treatment:

Procedure: Dental occlusion restoration

Intervention 2

Experimental group

Description:

Orthodontic treatment of malocclusion.

Treatment:

Procedure: Orthodontic treatment of malocclusion

Wait list control 2

Other group

Description:

Group of patients that will be evaluated until they receive the orthodontic treatment of malocclusion.

Treatment:

Procedure: Orthodontic treatment of malocclusion