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Oral Health Status in Patients With Cirrhosis and Effect of Dental Treatment on MELD Score of Cirrhosis Patients

P

Postgraduate Institute of Dental Sciences Rohtak

Status

Unknown

Conditions

Liver Cirrhosis
Periapical Lesions

Treatments

Procedure: Nonsurgical root canal treatment

Study type

Interventional

Funder types

Other

Identifiers

NCT04399512
swatiendo18787

Details and patient eligibility

About

It has been found that there is an association between prevalence of odontogenic infection and systemic diseases.Cirrhosis has also been associated with poor oral health status.Treating those patients accordingly can help in reducing the source of infection to some extent and may be associated with reduction in mortality.

Full description

Patients will be selected according to inclusion and exclusion criteria.Written informed consent will be taken from each participant after being informed about study .There will be two groups1) cirrhosis patients 2)normal healthy patients.Prevalence of apical periodontitis will be measured in both groups by intraoral examination,digital panoramic radiography.. MELD score will be recorded in cirrhosis patients at this stage.Non surgical root canal treatment will be performed in teeth with apical periodontitis. Periapical healing will be checked with the help of PAI Score given by Orstavik. In Cirrhosis patients MELD Score will be measured before and after treatment.

Enrollment

110 estimated patients

Sex

All

Ages

35 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:(cirrhosis patients)

  1. Known patient of cirrhosis(Diagnosis of cirrhosis is based on blood testing, medical imaging, and liver biopsy.) with mature permanent teeth .

  2. Age35-55 years

  3. > or equal to 8 natural teeth(excluding 3rd molars);

  4. I.N.R < 3.5

Exclusion Criteria:(Cirrhosis patients)

  1. Patient having systemic disorders other than hepatic disease(e.g. HIV, osteoporosis,diabetes,cardiovascular disease)
  2. Pregnancy
  3. Use of systemic and topical antibiotic treatment within 3 months prior to the start of the study.

The eligibility criteria of the control group were the same for the cirrhosis group, except for the presence of liver disease. Cirrhosis patients were matched with controls according to sex, age (± 3 years old) and current smoking status and alcohol satus (yes/no).

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

110 participants in 2 patient groups

Patients with liver cirrhosis
Active Comparator group
Description:
prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis and change in MELD(model for end stage liver disease) will be checked after treatment.
Treatment:
Procedure: Nonsurgical root canal treatment
Normal healthy patients
Active Comparator group
Description:
prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis
Treatment:
Procedure: Nonsurgical root canal treatment

Trial contacts and locations

1

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Central trial contact

Swati Sharma

Data sourced from clinicaltrials.gov

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