Oral Immunotherapy for Peanut and Mammalian Meat Allergies

University of Virginia

Status: Completed

Conditions: Food Hypersensitivity

Treatments: Dietary Supplement: cow's milk; Dietary Supplement: peanut powder

Study type: Interventional

Funder types: Other

Identifiers

NCT02350660

15098

Details and patient eligibility

About

Pilot study to assess the effect of oral immunotherapy on specific Immunoglobulin E (IgE) levels and antigen consumption in two distinct food allergies.

Full description

In subjects with mammalian meat allergy, the effect of daily oral cow's milk on immune parameters and desensitization will be assessed. Similarly, in subjects with a peanut allergy the effects of low dose peanut flour will be assessed and comparisons between two distinct food allergies.

Enrollment: 24 patients

Sex: All

Ages: 4 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Presence or absence of specific IgE to alpha-gal or peanut

Exclusion criteria

• History of severe anaphylaxis
• allergy to cow's milk protein

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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24 participants in 2 patient groups

Cow's milk for alpha-gal allergics

Experimental group

Description:

daily consumption of cow's milk

Treatment:

Dietary Supplement: cow's milk

Peanut powder

Experimental group

Description:

peanut oral immunotherapy

Treatment:

Dietary Supplement: peanut powder