Oral Microbiota and Oral Status of Adult Patients With Autism Spectrum Disorders (MICAA: MICrobiota Autism Adults)

Central Hospital, Nancy, France

Status: Completed

Conditions: Autism Spectrum Disorder

Treatments: Other: collection of saliva, gum fluid and/or dental plaque samples

Study type: Interventional

Funder types: Other

Identifiers

NCT05910424

2023-A01024-41

Details and patient eligibility

About

The goals of this pilot study are to assess the presence of harmful germs for gums and to assess oral health in adults with autism spectrum disorder.

Full description

Participants or their tutors will fulfill a form with general health information and daily habits.

Investigators will :

• collect saliva, gum fluid and/ or dental plaque to characterise germs
• assess gum health and oral hygiene
• register decays, filled and missing teeth.

Enrollment: 37 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• A person (or legal representative) who has received full information about the organisation of the research and accept to participate and the use of his or her data.
• Adult with autism spectrum disorder, men or women aged between 18 and 60.
• Member of a social security scheme or beneficiary of a medical insurance

Exclusion criteria

• Children under 18 with autism spectrum disorder
• Use of medication or situations that may affect the microbiota (use of antibiotics, probiotics, steroidal or non-steroidal anti-inflammatory drugs in the last 3 months, strict mouth breathing)
• Smoking
• Very lingual position of the teeth hindering clinical assessment of the periodontium
• Patients who have had periodontal treatment for less than 6 months
• Persons covered by articles L. 1121-5 to L. 1121-7 and L1122-2 of the French Public Health Code:
• Pregnant women, women in labour or breast-feeding mothers
• Persons deprived of their liberty by a judicial or administrative decision
• Persons unable to give their consent
• Person under psychiatric care by virtue of articles L. 3212-1 and L. 3213-1 of the Public Health Code
• Minor (not emancipated)

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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37 participants in 1 patient group

Adults with Autism Spectrum Disorder

Experimental group

Description:

* Adults with autism spectrum disorder * Aged between 18 and 60 years old * Dental cares and follow-up in Nancy hospital

Treatment:

Other: collection of saliva, gum fluid and/or dental plaque samples