Oral Mucosal Graft Versus Labial Graft in Female Urethroplasty

Tanta University

Status: Enrolling

Conditions: Urethroplasty; Female; Labial Graft; Oral Mucosal Graft

Treatments: Procedure: Labial graft; Procedure: Oral mucosal graft

Study type: Interventional

Funder types: Other

Identifiers

NCT07153861

36264PR1113/2/25

Details and patient eligibility

About

This study aims to compare the oral versus labial graft in female urethroplasty in female urethral stricture.

Full description

Female urethral stricture is an uncommon condition with an estimated prevalence of 4%-13% in women with bladder outlet obstruction.

Urethral reconstruction may become the treatment of choice in stricture recurrence following the failure of minimally invasive procedures. and the use of flaps and grafts has all been proposed. Different materials (e.g., vaginal and genital mucosal graft or flap, bladder mucosal flap, and oral mucosal graft) have been reported for augmentation urethroplasty.

Enrollment: 40 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female patients with urethral stricture.
• Female patients with non-traumatic urethral stricture.

Exclusion criteria

• Female patients with traumatic urethral stricture.
• Female patients with systemic contraindications of surgery like bleeding disorders.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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40 participants in 2 patient groups

Group 1

Experimental group

Description:

Patients will be admitted for the surgical management by the oral mucosal graft urethroplasty with the anterior onlay technique.

Treatment:

Procedure: Oral mucosal graft

Group 2

Experimental group

Description:

Patients will be admitted for the surgical management by the labial graft urethroplasty with the anterior onlay technique.

Treatment:

Procedure: Labial graft