Oral Nutritional Supplement Intervention Among Hemodialysis Patients With Sarcopenic Obesity

Buddhist Tzu Chi Medical Foundation

Status: Unknown

Conditions: Sarcopenic Obesity; Chronic Kidney Disease Requiring Chronic Dialysis; Body Composition

Treatments: Dietary Supplement: ReGen 18%

Study type: Interventional

Funder types: Other

Identifiers

NCT03347773

06-M05-079

Details and patient eligibility

About

Chronic kidney disease patients with sarcopenic obesity are noted to have impairment in physical performance and reducing their quality of life, and the investigators also founded these patients are at higher risk of mortality. Thus, the investigators hypothesize that oral nutrition intervention could increase lean tissue mass in these patients and improve the clinical outcomes.

Full description

In chronic kidney disease (CKD) patients, disease- and age- related changes in body composition, as well as the increased prevalence of obesity, determine a combination of excess weight and reduced muscle mass or strength, recently defined as sarcopenic obesity. The prevalence of sarcopenic obesity increase with lower eGFR, and previous studies showed that up to 18.3% stage 4 CKD patients and 56% prevalent hemodialysis patient to be with sarcopenic obesity. Sarcopenic obesity was negatively correlated with physical performance and quality of life. In the investigator's previous study, nondialysis-dependent CKD patients with normal body mass index (BMI) but excess body fat had the highest risk of death compared to those with BMI above the cutoff for obesity and excess body fat during a follow up of 5 years. These patients with excess body fat but lower lean tissue mass was what so called "sarcopenic obesity" group.

Hemodialysis therapy per se has been shown to be a catabolic process. Pupim et al. showed that in eight malnourished patients undergoing hemodialysis, highly positive whole-body net protein balance during hemodialysis and improvement of skeletal muscle protein homeostasis was achieved with an intradialytic oral nutritional supplement (ONS) compared to the control, and ONS during hemodialysis resulted in persistent anabolic benefits for muscle protein metabolism in the posthemodialysis phase. In the past, randomized trials of nutritional supplement intervention in dialysis patients were focused on populations with protein energy wasting, and most studies used change in serum albumin concentration as the surrogate marker. Studies focused on dialysis patients with sarcopenic obesity are sparse. Therefore, the investigators hypothesize that ONS could improve the nutritional status among dialysis patients with sarcopenic obesity, especially increase in lean tissue, and improve clinical outcomes. This pilot/feasibility study is aimed to conduct a randomised controlled pilot trial of the feasibility of undertaking a study to assess the effect of ONS on the nutritional status of haemodialysis patients with sarcopenic obesity and will lead to a more robust definitive trial in the future.

Enrollment: 60 estimated patients

Sex: All

Ages: 40 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 40 y/o and 90 y/o
• Regular hemodialysis treatment at least 3 months
• Hemodialysis treatment thrice a week, 3.5-4.5 hours/session
• Body composition: body mass index < 28 kg/m2 and body fat percentage >25% for males or >35% for females
• The normalized protein catabolic rate (nPCR) < 1.2 g/kg/day

Exclusion criteria

• Inadequate Kt/V <1.2
• Active malignancy
• Liver cirrhosis
• Active infection, including tuberculosis and AIDS
• Kidney transplant less than 6 months before study enrollment
• Patients hospitalized for more than 5 days within 3 months preceding enrollment
• Patients received intradialytic parental nutrition within 2 months preceding enrollment
• Inability to perform hand grip test, including patients with NG feeding or under bed-ridden status
• Patients with a cardiac pacemaker or metallic implants
• Patients are amputees
• Pregnant woman
• History of poor adherence to dialysis or medication

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Intervention

Experimental group

Description:

The subjects will be assigned to receive nutritional supplement consisting of one can of ReGen 18% (19.1 g protein, 425 Kcal) daily and standard care.

Treatment:

Dietary Supplement: ReGen 18%

Control

No Intervention group

Description:

The subjects will be assigned to receive standard care alone.