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Oral Peptones Load in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism and Healthy Subjects

U

University of Eastern Piedmont

Status

Completed

Conditions

Hypercalcemia
Hyperparathyroidism

Treatments

Other: Oral peptones load

Study type

Interventional

Funder types

Other

Identifiers

NCT01042626
NO012010

Details and patient eligibility

About

The purpose of this study is to assess if subjects with hyperparathyroidism with normal serum calcium levels have different responses in the calcium regulating hormonal handling compared to a) patients with primary hyperparathyroidism and high serum calcium levels; b) healthy subjects.

The differences will be evaluated with oral peptones load and subsequent blood samples collected every 15 minutes for two hours. Ionized calcium, phosphate, gastrin and PTH levels will be evaluated.

Enrollment

60 patients

Sex

All

Ages

18 to 90 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  1. normocalcemic hyperparathyroidism

    • presence of high serum levels of intact PTH
    • serum ionized calcium levels in the high normality range
  2. hypercalcemic hyperparathyroidism

    • presence of high serum levels of intact PTH
    • high serum ionized calcium levels

Exclusion criteria

  1. potential causes of secondary hyperparathyroidism like renal insufficiency, liver disease, malabsorption, hypercalciuria, Paget's disease, thiazide diuretic or lithium use.
  2. bone disease of any origin

Trial design

60 participants in 3 patient groups

Normocalcemic Hyperparathyroidism
Experimental group
Treatment:
Other: Oral peptones load
Hypercalcemic Hyperparathyroidism
Experimental group
Treatment:
Other: Oral peptones load
Healthy subjects
Active Comparator group
Treatment:
Other: Oral peptones load

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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