Oral Probiotics for Halitosis in Healthy Adults

John Hale

Status: Begins enrollment in 1 month

Conditions: Halitosis

Treatments: Other: Placebo; Dietary Supplement: In this study, a probiotic lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath

Study type: Interventional

Funder types: Industry

Identifiers

NCT07384130

2025EXP24497 (Other Identifier)

BLTCT2025/1

Details and patient eligibility

About

The aim of this study is to evaluate efficacy of a probiotic lozenge containing BLIS M18, BLIS K12 and a prebiotic in healthy adults.

Full description

This is a double-blind, randomized controlled colonization pilot study with no crossover to evaluate the efficacy of probiotic lozenges on halitosis in healthy adults.

Participants will be randomly assigned to 2 groups consuming probiotic lozenge containing Streptococcus salivarius M18 and K12 and with prebiotic over a 13 day period. Breath scores will be measured at predetermined time points pre and post intervention.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participants should be otherwise healthy,
• practice good oral hygiene,
• 18 - 70 years of age

Exclusion criteria

• on antibiotic therapy,
• immunocompromised (have a weakened immune system)
• history of autoimmune disease,
• allergy or sensitivity to dairy,
• have an active periodontal disease, any known allergy or sensitivity to components of the test product or cysteine solution.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

40 participants in 2 patient groups, including a placebo group

Oral probiotic lozenges

Active Comparator group

Description:

Oral probiotic lozenges containing Streptococcus salivarius M18 and Streptococcus salivarius K12 and prebiotic

Treatment:

Dietary Supplement: In this study, a probiotic lozenge formulation containing S. salivarius K12, M18 and prebiotic will be evaluated for its potential to improve bad breath

Placebo lozenges

Placebo Comparator group

Description:

Oral lozenges

Treatment:

Other: Placebo