Oral Water Ingestion in Heart Transplant Patients

Satish R. Raj

Status: Active, not recruiting

Conditions: Cardiac Transplantation; Blood Pressure

Treatments: Dietary Supplement: water

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00581321

050811

UL1RR024975 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

In this study the investigators propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. The investigators will test the hypothesis that water ingestion will increase the systemic vascular resistance.

Full description

In this study we propose to assess the hemodynamic response to the ingestion of 16 fl oz of water. We will test the hypothesis that water ingestion will increase the systemic vascular resistance. This study will occur in patients status post cardiac transplantation during their clinical right heart catheterizations. Invasive hemodynamics including cardiac outputs and plasma norepinephrine levels will be measured before and 30 min after the water ingestion.

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• s/p cardiac transplantation scheduled for clinical right heart catheterization
• age > 18 years

Exclusion criteria

• significant tricuspid regurgitation
• inability to safely swallow 500 ml of water
• other major medical comorbidities such as advanced renal disease where water ingestion may be harmful to patient

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

1

Experimental group

Description:

water ingestion (16 fl oz within 3 minutes)

Treatment:

Dietary Supplement: water