Oral Zinc Supplement as Adjunctive Therapy for Erosive Oral Lichen Planus

Hams Hamed Abdelrahman

Status

Completed

Conditions

Oral Lichen Planus

Treatments

Drug: triamcinolone acetonide Oral paste

Drug: Oral zinc supplement

Study type

Interventional

Funder types

Other

Identifiers

NCT06042010

Oral medicine_0424-04\2022

Details and patient eligibility

About

Lichen Planus (LP) is a chronic mucocutaneous inflammatory disease and considered as T-cell mediated autoimmune disorder.

Zinc is a potent antioxidant micronutrient that contributes to the proper functioning of the antioxidant defense system. In addition, this mineral protects cells against inflammation by oxidative stress, because it acts in the stabilization of cell membrane. It also maintains macrophage and neutrophil functions, natural killer cell activity, and complement activity.

Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases and have the main function of proteolytic degradation of connective tissue matrix proteins. Zinc prevents (MMP-1) activation and inhibition of the T-cell accumulation in (OLP) through inhibiting of (MMP-9).

Aim of the study: To evaluate and compare the efficacy of adding oral zinc supplementation 50 mg to 0.1%Triamcinolone orabase (TA)versus 0.1%Triamcinolone orabase alone on the healing of erosive OLP.

Enrollment

22 patients

Sex

All

Ages

25+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All patients involved in this clinical trial will have symptomatic OLP

Exclusion criteria

Smokers or tobacco users will be excluded from this clinical trial.
Pregnant and lactating females.
Any patient that has history of cancer, kidney, liver or other autoimmune disease will be excluded from this study.
Patients showing dysplastic changes in their confirmatory biopsy specimen will be also excluded.
Any patients presenting with extra oral lichen planus lesions will be excluded.
Suspicious lesions of both lichenoid contact reaction and lichenoid drug reaction lesions will be excluded.
Vitamin administration intake within the last 3 months