Orange Juice Consumption and Glucose Metabolism and Antioxidative Status

University of Hohenheim

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Orange juice between meals; Dietary Supplement: Sugar sweetened beverage between meals; Dietary Supplement: Orange juice with meals

Study type: Interventional

Funder types: Other

Identifiers

NCT02974478

OrangeJuice

Details and patient eligibility

About

Aim of the study is to investigate the impact of orange juice consumption (with meals or between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on glucose homeostasis and antioxidative status.

Full description

Duration of the study is 3x three weeks including one wash-out week each followed by two weeks of juice/SSB consumption under free living conditions.

During wash-out weeks consumption of orange juice or citrus fruits is restricted.

During intervention weeks, participants are asked to eat three regular meals per day without snacking. Intervention weeks are (i) orange juice consumption with meals (ii) orange juice consumption between meals and (iii) SSB consumption between meals. Daily energy intake with orange juice/SSB is 20% of individual energy requirement. Additional caloric beverages (SSB, juice, coffee with sugar/milk, alcohol) are not allowed. At the beginning and the end of each intervention phase insulin sensitivity and antioxidative status are assessed.

Enrollment: 26 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy

Exclusion criteria

• regular use of medication,
• smoking,
• chronic disease,
• vegan/vegetarian diet,
• fructose intolerance,
• irregular eating behaviour (less then 3 meals/day)

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

26 participants in 3 patient groups

Orange juice with meals

Experimental group

Description:

Effect of orange juice consumption with three meals per day (without snacking) on glucose metabolism and antioxidative status

Treatment:

Dietary Supplement: Orange juice with meals

Orange juice between meals

Experimental group

Description:

Effect of orange juice consumption between three meals per day (without snacking) on glucose metabolism and antioxidative status

Treatment:

Dietary Supplement: Orange juice between meals

Sugar sweetened beverage between meals

Experimental group

Description:

Effect of sugar sweetened beverage consumption between three meals per day (without snacking) on glucose metabolism and antioxidative status

Treatment:

Dietary Supplement: Sugar sweetened beverage between meals