Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children (ORBIT)

School of Health Sciences Geneva

Status: Enrolling

Conditions: Behavior; Development, Child; Music; Interventions; Executive Functions; Brain Plasticity; Structural Brain Connectivity; Arts; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Brain Imaging

Treatments: Behavioral: Orchestra in Class

Study type: Interventional

Funder types: Other

Identifiers

NCT05912270

126645

Details and patient eligibility

About

How to optimally stimulate the developing brain is still unclear. Executive functions (EF) exhibited substantially stronger far transfer effects in children who learned to play a musical instrument than in children who acquired other arts.

What is crucially lacking is a large-scale, long-term genuine randomized controlled trial (RCT) in cognitive neuroscience, comparing musical instrumental training (MIP) to another art form and a control group. Collected data of this proposal will allow, using machine learning, to build a data-driven multivariate model of children's interconnected brain and EF development over the first 2 years of their academic curriculum (6-8 years), with or without music or other art training.

Full description

This cognitive neuroscience study, employing a randomized controlled trial (RCT), aims to investigate the potential cognitive and brain development benefits in young school children from two-year interventions: Orchestra in Class (OC, music practice, experimental group) compared with Visual Arts (VA, second experimental group) versus Standard Education (active control group (CG)). The CG will be offered six cultural outings per year (concerts, museums, theatres, etc.). Both nonverbal art interventions will be given weekly interventions for 1 hour and 30 minutes in school class sized groups. The VA groups serve to control for the influences of regular stimulating group interventions and homework, and also to compare specific effects in visual mode with the auditory mode in OC. The CG controls for overall child development and test-retest effects.

We plan to recruit 150 children aged 6-8 years from public elementary schools, ensuring a random and therefore equal distribution among the three groups. Data collection will involve annual comprehensive psychometric testing (baseline, after 1 year, after 2 years) of executive functions, i.e., far transfer and near transfer, musicality, drawing, academic achievement, and multimodal structural and functional magnetic resonance imaging (fMRI), including fMRI with auditory and visual domain working memory tasks.

By utilizing multivariate analyses and integrating behavioral and brain data through machine learning, we aim to create a data-driven model of the development of executive functions at the behavioral and brain levels in young children at the beginning of their school careers (6 to 8 years old), both without and with an enriched environment (musical practice versus visual arts)

Enrollment: 150 estimated patients

Sex: All

Ages: 6 to 8 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• School grade 3P/4P (3rd and 4th year of elementary school (6-8-year-old children)
• Right-handedness
• Sufficient Mastery of the French Language
• Able to give oral informed consent (child)
• Able to give written informed consent (parent)

Exclusion criteria

• Non-consent (children and or parents)
• Repeated or skipped a class with respect to standard curriculum
• Not corrected/severe hearing deficits
• Not corrected/severe vision deficits
• Severe neurodevelopmental disorders (eg. severe dyslexia, severe ADHD)
• Older than 7 at the beginning of the school year if 3P
• Older than 8 at the beginning of the school year if 4P
• Protocolled music instrumental practice in the preceding year
• Protocolled visual arts courses in the preceding year
• MRI incompatibility (physical or psychological)
• Psychometric battery incompatibility (psychological)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

150 participants in 3 patient groups, including a placebo group

Orchestra in Class

Experimental group

Description:

Children will receive music practice lessons in groups, "Orchestra in Class" (4 different string instruments, violin, viola, cello, double bass) in school class size groups over 2 full years. Interventions, given by 2 professional teachers per class, take place for 1 hour and 30 minutes per week, completed by daily homework (20-30 minutes).

Treatment:

Behavioral: Orchestra in Class

Visual Arts

Experimental group

Description:

Children will receive visual arts lessons in school class size groups over 2 full years. Interventions, given by 2 professional teachers per class, take place for 1 hour and 30 minutes per week, completed by daily homework (20-30 minutes).

Treatment:

Behavioral: Orchestra in Class

Culture

Placebo Comparator group

Description:

The children will receive six cultural outings per year (museums, concerts, theatre, etc.) and pass all measurements

Treatment:

Behavioral: Orchestra in Class