Orexin-A Levels in Insomnia Patients

Muğla Sıtkı Koçman University

Status: Completed

Conditions: Insomnia; Anesthesia

Treatments: Diagnostic Test: Jenkins Sleep Disorders scale and Epworth Sleepiness scale

Study type: Observational

Funder types: Other

Identifiers

NCT05664295

14/III

Details and patient eligibility

About

In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.

Full description

ASA (American Society of Anesthesiologists) I-II patients aged 18-65 years who underwent elective laparoscopic cholecystectomy were included in the study. Patients were evaluated with the Jenkins Sleep Disorders scale and Epworth Sleepiness scale during preoperative examination and were divided into insomnia and control groups. Blood samples were obtained for OXA and glucose levels at anesthesia induction, 5 minutes after extubation and 30 minutes after extubation. The times from stopping anesthesia to eyes opening and extubation and end-tidal sevoflurane concentrations at these time points were recorded.

Enrollment: 60 patients

Sex: Male

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male patients undergo elective laparoscopic cholecystectomy under general anesthesia
• Between 18-65 age
• ASA I-II

Exclusion criteria

• ASA≥III
• Patients with obstructive sleep apnea syndrome
• Bleeding over 500 ml
• Allergic to anesthetic agents
• Patients with a BMI > 30 kg/m2

Trial design

60 participants in 2 patient groups

insomnia patients

Description:

Jenkins Sleep Disorders scale skor \>1 and Epworth Sleepiness scale skor \>9

Treatment:

Diagnostic Test: Jenkins Sleep Disorders scale and Epworth Sleepiness scale

noninsomniacs

Description:

Jenkins Sleep Disorders scale skor \<2 and Epworth Sleepiness scale skor \<10

Treatment:

Diagnostic Test: Jenkins Sleep Disorders scale and Epworth Sleepiness scale