Orexin Gene in Anorexia Nervosa (ORESSANNE)

Istituto Auxologico Italiano

Status: Enrolling

Conditions: Anorexia Nervosa

Treatments: Other: Blood samples and Questionnaires

Study type: Observational

Funder types: Other

Identifiers

NCT06800898

01C414

Details and patient eligibility

About

The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.

Enrollment: 60 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patients with Anorexia Nervosa:

Inclusion Criteria:

• Female sex
• Age 18 years and older
• Anorexia Nervosa
• Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy

Exclusion Criteria:

• Absence of signed informed consent

Control group:

Inclusion Criteria:

• Female sex
• Age 18 years and older
• Body Mass Index between 18.5 and 24.9 kg/m2

Exclusion Criteria:

• Absence of signed informed consent
• Presence of any physical and mental pathology

Trial design

60 participants in 2 patient groups

Anorexia Nervosa

Description:

Young women with Anorexia Nervosa, hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy,

Treatment:

Other: Blood samples and Questionnaires

Normal weight

Description:

Young women of comparable age with Body Mass Index between 18.5 and 24.9 kg/m2

Treatment:

Other: Blood samples and Questionnaires