Organ Protection With Sevoflurane Postconditioning

University of Zurich (UZH)

Status: Completed

Conditions: Hepatectomy

Treatments: Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT00518908

StV 34-2007

Details and patient eligibility

About

Organ protection, volatile anesthetics, postconditioning, hepatic surgery

Full description

This study aims at the evaluation of a potential attenuation of ischemic-reperfusion injury in the liver with sevoflurane postconditioning upon reperfusion.

Enrollment: 125 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• older than 18 years
• patients undergoing liver resection (benign or malignant tumors)

Exclusion criteria

• non-german speakers
• laparoscopic liver resection
• coagulopathy (platelets < 50'000/ml, Quick < 50%)
• liver cirrhosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

125 participants in 2 patient groups

Sevoflurane

Experimental group

Description:

Sevoflurane for pharmacological postconditioning

Treatment:

Drug: Sevoflurane

Propofol

Experimental group

Description:

Anesthesia maintenance with propofol instead of Sevoflurane postconditioning

Treatment:

Drug: Sevoflurane