Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

University of Zurich (UZH)

Status: Completed

Conditions: Cardiac On-pump Surgery

Treatments: Drug: Sevoflurane; Drug: Propofol

Study type: Interventional

Funder types: Other

Identifiers

NCT00924222

IFA-5-2007

Details and patient eligibility

About

Organ protection, volatile anesthetics, postconditioning.

Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.

Enrollment: 120 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• CABG and/or heart valve surgery with CPB
• Ejection fraction (EF) = 30%
• Canadian Cardiovascular Society (CCS) classification = 3
• Ages 18 to 90 years old

Exclusion criteria

• Pulmonary disease: forced expiratory volume in one second (FEV1) < 80%; FEV1/forced vital capacity (FVC) < 70%
• Renal disease and/ or creatinine-clearance < 60 ml/min
• Previous cardiac surgery
• Emergency procedures
• Postoperative intra aortic balloon pump (IABP) requirement
• Myocardial infarction < 7d
• Steroid treatment
• Insulin-dependent diabetes
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Sevoflurane

Experimental group

Treatment:

Drug: Propofol

Drug: Sevoflurane

Propofol

Experimental group

Treatment:

Drug: Propofol

Drug: Sevoflurane