Orientation Agnosia: Clinical and Anatomical Study (AGNORIENT)

University Hospital, Rouen

Status: Completed

Conditions: Brain Lesions; Cerebrovascular Disorders

Treatments: Behavioral: Neuropsychological testing; Other: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT01304576

2009/126/HP

number ID RCB 2009-A01005-52 (Other Identifier)

Details and patient eligibility

About

The area of the brain responsible of visuospatial processing data and more specifically the orientation of an object or image is located in parietal lobe, especially on the right side. A dysfunction of this region would result in a disorder of recognition of the orientation of objects and images that the investigators call orientation agnosia. Several isolated cases are reported in the literature but to the investigators knowledge deficit has never been systematically searched, or put into perspective compared to other neuropsychological deficits. Moreover, the precise location of the lesion responsible for such a disorder remains uncertain. The objectives of this study are (1) detect the existence of orientation agnosia in case of right parietal lesion, and (2) to improve the understanding of such a deficit allowing better management of this disorder.

Full description

Idem

Enrollment: 34 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 18 and 80 years
• french language
• right parietal lesion on cerebral imaging (CT-scan is sufficient), including stroke,arterial malformation, isolated tumoral lesion
• informed consent

Exclusion criteria

• previous neurological history except non complicated migraine and stabilized epilepsia without seizure since 5 years
• previous psychiatric history except depression without hospitalization > one week or anxiety with maximum one anxiolytic treatment
• drug or alcohol abuse
• severe cranial traumatism
• other severe chronic pathology
• psychotropic medication other than a hypnotic or an anxiolytic at low doses without dose modification for at least one month
• visual impairment
• motor or sensory deficit sufficient to render impossible neuropsychological tests
• patient without judicial or administrative liberty
• measure of legal protection or no capable to express their consent
• pregnancy or breastfeeding

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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34 participants in 2 patient groups

patient with right parietal lesions

Experimental group

Treatment:

Other: MRI

Behavioral: Neuropsychological testing

patient with left parietal lesions

Active Comparator group

Treatment:

Other: MRI

Behavioral: Neuropsychological testing