Orthodontic Treatment on Oral Microbiota and Salivary Proteins

Xi'an Jiaotong University

Status: Not yet enrolling

Conditions: Orthodontics; White Spot Lesions [Initial Caries] on Smooth Surface of Tooth; Caries, Dental

Treatments: Other: no interventions; Other: No Intervention: Observational Cohort; Other: None-placebo

Study type: Observational

Funder types: Other

Identifiers

NCT06824493

XJKQLY202503

Details and patient eligibility

About

Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.

Enrollment: 150 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No carries and White spot
• No missing teeth
• No history of oral treatment
• No malocclusion
• No systemic diseases

Exclusion criteria

• Antibiotic use in the past three months
• A history of long-term medication use
• A history of dental fillings
• Unable to attend regular follow-ups

Trial design

150 participants in 1 patient group

ID number

Treatment:

Other: None-placebo

Other: No Intervention: Observational Cohort

Other: no interventions