Oscillation Mechanics of the Respiratory System in Never-smoking Patients With Silicosis

Rio de Janeiro State University

Status: Completed

Conditions: Silicosis

Study type: Observational

Funder types: Other

Identifiers

NCT01725971

Silicose2012 (Other Identifier)

Details and patient eligibility

About

Silicosis is a chronic and incurable occupational disease that can progress independent of the end of exposure. Recent works suggest that the Forced Oscillation Technique (FOT) may help to improve our understanding of the changes in lung mechanics, as well as in the detection of these changes.

Objectives: Analyze the effects of airway obstruction in silicosis on the respiratory impedance and evaluated the diagnostic use of the FOT in these patients. For this, the investigators used spirometry to classify airway obstruction, which resulted in four categories: control, patients with normal exam, mild obstruction, and moderate-to-severe obstruction. Resistive data were interpreted using the zero-intercept resistance (R0), the resistance at 4 Hz (Rrs4) and the mean resistance (Rm). The investigators also analyzed the mean reactance (Xm) and the dynamic compliance (Crs,dyn). The total mechanical load was evaluated using the absolute value of the respiratory impedance (Z4Hz). The diagnostic potential was evaluated by investigating the area under the receiver operating characteristic curve (AUC).

Enrollment: 67 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Volunteers with silicosis for Patients Group;

  • Volunteers without any respiratory disease for the control group.

Exclusion criteria

• Smokers

Trial design

67 participants in 4 patient groups

Control group

Description:

Group of nonsmokers individuals without respiratory disease.

normal exam

Description:

subjects with silicosis , but with normal spirometric data

mild obstruction

Description:

subjects with silicosis with mild obstruction in spirometric data

moderate to severe obstruction

Description:

subjects with silicosis with moderate to severe obstruction in spirometric data