Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement (BAG-OSMOV)

University Hospital of Bordeaux

Status

Enrolling

Conditions

Epilepsy

Parkinson Disease

Treatments

Procedure: High Resolution Electroencephalogram (EEG-HR)

Procedure: Stereo-electro-encephalography (SEEG)

Study type

Interventional

Funder types

Other

Identifiers

NCT06241924

CHUBX 2022/80

Details and patient eligibility

About

The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range.

The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.

Full description

In order to define the link between the characteristics of the oscillations (frequency, amplitude, phase relation) within this cortico-subcortical network and movement (normal or pathological) in humans, a simple motor task of gripping/pulling a lever has been designed.

The local field potentials (LFPs) will be collected during the same motor task in :

i) patients with Parkinson's disease, using a high-resolution electroencephalogram (EEG) and the PERCEPT(TM) system (Medtronic) equipped with a "sensing" function for deep LFP recordings and in EEG-HR (for high resolution) for cortical recordings

ii) patients with focal drug-resistant epilepsy, during a pre-surgical assessment by stereo-electro-encephalography (SEEG). The SEEG allows the recording of both the cortex and the subcortical regions in a concomitant manner, and a direct correlation can be studied.

Enrollment

30 estimated patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria :

Male or Female
Between 18 and 75 years of age
With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
Giving free, informed, written consent signed by the participant and the investigator Or
With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
With at least one electrode exploring the basal ganglia or the thalamus.
Able to perform the simple motor task
Affiliated or beneficiary of a social security scheme;
Giving free, informed, written consent signed by the participant and the investigator

Exclusion criteria:

Be incapable of giving consent personally
Be subject to a legal protection measure or be placed under judicial protection;
Being pregnant or breastfeeding
Present a serious and/or decompensated somatic or psychiatric illness