Oslo Randomized Laparoscopic Versus Open Liver Resection for Colorectal Metastases Study (Oslo-CoMet)

University of Oslo (UIO)

Status

Active, not recruiting

Conditions

Secondary Malignant Neoplasm of Liver

Colorectal Neoplasms

Treatments

Procedure: Laparoscopic liver resection

Procedure: Open liver resection

Study type

Interventional

Funder types

Other

Identifiers

NCT01516710

2011/1285/REK sør-øst B

Details and patient eligibility

About

The purpose of the study is to compare outcomes of laparoscopic versus open liver resection for colorectal metastases in a prospective and randomized study. The study will include all non-anatomic liver resections in our institution.

The primary end point is that the use of laparoscopic technique significantly can reduce the frequency of complications to liver resection. Secondary end points are 5-year survival, immediate surgical outcomes, quality of life and degree of impairment of the immune system.

Full description

Full protocol is published open access in Trialsjournal:

http://www.trialsjournal.com/content/16/1/73

Enrollment

280 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients eligible for radical liver resection without formal liver resection or without assistance of radiofrequency ablation

Exclusion criteria

Inability to give written informed concent
Patients with tumors that can't be resected without reconstruction of vessels or bile ducts
Patients with tumors that can't be resected without 1)formal liver resection 2)combination with radiofrequency ablation
Patients with extrahepatic metastasis except resectable metastasis in lungs and adrenals
Pre- and peroperative diagnosis of non radically treatable disease