Osteoarthritis: Weakness From Inflammation

National Institutes of Health (NIH)

Status: Completed

Conditions: Osteoarthritis

Study type: Observational

Funder types: NIH

Identifiers

NCT00104312

AG0016

Details and patient eligibility

About

The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.

Full description

Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.

This study requires 1 four-hour visit to Harbor Hospital. The visit involves a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, strength testing and a surface electromyography (EMG). Samples of muscle, joint fluid and joint tissue will be collected during your planned surgery.

Participation in this study is entirely voluntary.

Enrollment: 88 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 50 years of age or older
• Normal body weight (a Body Mass Index (BMI) of 30 or less)
• Osteoarthritis of the knee (prior to knee surgery)
• Planning to have knee surgery at a MedStar Hospital

Exclusion criteria

• History of a stroke
• History of muscle weakness or paralysis
• History of Rheumatoid Arthritis or
• Inflammatory Joint Disease
• History of a Bleeding Disorder
• History of Gout
• Diabetes for which you take insulin
• Polymyalgia rheumatica (total body muscle aching/stiffness)

Trial design

88 participants in 2 patient groups

1

Description:

Participants with symptomatic knee osteoarthritis

2

Description:

Participants without symptomatic knee osteoarthritis, age-matched as controls