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Osteoclast Impairment in Chronic Periodontitis by Regenerative Materials.

M

Meenakshi Ammal Dental College and Hospital

Status

Completed

Conditions

Osteoclastic Bone Loss
Periodontal Bone Loss
Periodontal Disease

Treatments

Other: other : PRF

Study type

Interventional

Funder types

Other

Identifiers

NCT03227367
MU-107-IEC/2014

Details and patient eligibility

About

The present study is an effort to investigate the hypothesis that Platelet Rich Fibrin/Biphasic Calcium Phosphate may play a role in inhibiting osteoclasts differentiation and in bone loss.

Full description

Study design

Fifty-five individuals from a suburban population were recruited. Out of them, 5 individuals refused to participate in the study. Finally, 50 participants were selected and divided into two groups, control group [Healthy individuals]: 25 Males/Females, aged 25 to 35 years and test group [Chronic periodontitis patients]: 25 Males/Females aged 30 to 45 years.

Demographic variables and periodontal parameters were measured in both the groups.The investigators explored the effect of Platelet rich fibrin (PRF)/Biphasic calcium phosphate (BCP) on differentiation and survival of osteoclasts obtained from peripheral blood of Chronic Periodontitis patients.

Enrollment

50 patients

Sex

All

Ages

25 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria: (Control group)

  • Subjects with age group between 30 to 45 years.
  • Non-smokers.
  • No previous history of periodontal treatment.

Inclusion Criteria: (Test group)

  • Subjects with age group between 30 to 45 years.
  • Presence of atleast 20 teeth
  • More than 30% of the sites with clinical attachment loss.
  • Non-smokers.
  • No previous history of periodontal treatment.

Exclusion Criteria: ( both the groups)

  • Individuals with systemic disease
  • Subjects under antibiotics or anti-inflammatory drugs within the previous 3 months.
  • Pregnant and lactating women.
  • Allergic to antibiotics.

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

50 participants in 2 patient groups

Test group
Experimental group
Description:
Mononuclear cells isolated from the peripheral blood of 25 chronic periodontitis patients were interveened with 1ml/well preparation of Platelet rich fibrin(PRF), Biphasic calcium phosphate (BCP) and PRF and BCP combination in-vitro.
Treatment:
Other: other : PRF
control group
Other group
Description:
Mononuclear cells isolated from the peripheral blood of healthy individuals in-vitro.
Treatment:
Other: other : PRF

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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