Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling

China Medical University

Status: Completed

Conditions: Primary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01323894

DMR-99-IRB-122

Details and patient eligibility

About

The first year purpose:

The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

Full description

Our previous work is investigating the viral (Adv-BMP-2) administration for the development of a model to generate bones for possible use in clinical settings; the non-viral and viral administrations will be compared for best osteogenesis effects.

The first year purpose:

The best concentration of canonical Wnt3a will be investigated in promoting the osteoblastogenesis of human mesenchymal stem cells.

Enrollment: 3 patients

Sex: All

Ages: 10 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age above 10 years old
• The patients require surgery ner iliac or abdomen areas

Exclusion criteria

• age below 10 years old