Osteogenic Potential of Cissus Quadrangularis Alveolar Ridge Distraction

Al-Azhar University

Status and phase: Completed; Phase 2

Conditions: Dental Implant; Distraction of Bone

Treatments: Drug: Cissus Quadrangularis

Study type: Interventional

Funder types: Other

Identifiers

NCT04669795

Al-AlAzhar University

Details and patient eligibility

About

Deficient alveolar mandibular ridge corrected distraction osteogenesis to facilitate dental implant placement. Patients grouped into 2 groups: one group received Cissus quadrangularis during the consolidation period, and the other group received placebo.

Full description

OPGs were taken immediately after distractor placement, at end of activation period, at 1st,2nd month of consolidation period, and at end of consolidation period. Change in bone height was evaluated immediately after distractor placement, at end of activation and end of consolidation periods.

CBCT were taken immediately after implant installation, and 6 months later to evaluate change bone density and marginal bone level about the dental implant.

histological evaluation was done by biopsy obtained, by trephine bur, from implant site during its preparation. The bone biopsy fixed in 4% formalin solution for 7 days, rinsed in water, and dehydrated in sequent phases of ethanol (70, 80, 90, and 100%) and then specimens were stained by hematoxylin- eosin for microscopic evaluation.

Radiographic evaluation

Enrollment: 20 patients

Sex: All

Ages: 30 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients were included if they were free from any disease that may affect healing. Also, presented with 2-3 missing teeth at least in posterior area and CBCT showed bone height above inferior alveolar canal (IAC) ranged 8-10mm.

Exclusion criteria

• patients were excluded if they suffered from any disease affect tissue healing, bad oral hygiene or heavy smoking patients

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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20 participants in 2 patient groups, including a placebo group

Group 1

Placebo Comparator group

Description:

Placebo was given to ten patients during consolidation period ( 2 capsule daily for 6 months during consolidation period)

Treatment:

Drug: Cissus Quadrangularis

Group 2

Experimental group

Description:

Cissus quadrangularis in form of capsules given to ten patients ( 2 capsule daily for 6 months during consolidation period)

Treatment:

Drug: Cissus Quadrangularis