Osteoporosis After Stroke

Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Status: Not yet enrolling

Conditions: Osteoporosis; Stroke

Treatments: Diagnostic Test: Bone mineral density/ Bone mineral density (BMD) will be measured on the lumbar spine (L1-L4) and femoral neck by dual X-ray absorptiometry (DXA)

Study type: Observational

Funder types: Other

Identifiers

NCT07059468

E-34225015 06/001

Gaziler

Details and patient eligibility

About

The aim of this study was to investigate the clinical features affecting bone mineral density in plegic and non-plegic extremities in hemiplegic patients with stroke in the subacute and chronic phases.

Full description

One of the common complications after stroke is secondary osteoporosis that develops due to stroke. The most important event that draws attention to bone health in stroke patients is fractures, the most serious of which in terms of morbidity and mortality are hip fractures. The risk of hip fracture in stroke patients is 2-4 times higher than the normal population due to the decrease in bone mineral density on the plegic side and the increased risk of falling. There is a loss of bone mineral density after stroke. This loss is faster and larger in the early stages of stroke and is greater on the plegic side. The factors affecting this loss of bone mineral density after stroke have not been well defined. The relationship between stroke-related bone mineral density loss and motor function, functional mobility, balance, and muscle mass is not clear. It is important to reveal the changes in bone structure after stroke and the factors affecting this change. The aim of this study was to investigate the clinical features affecting bone mineral density in plegic and non-plegic extremities in hemiplegic patients with stroke in the subacute and chronic phases.

Enrollment: 44 estimated patients

Sex: All

Ages: 40 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 40-65 years with a unilateral stroke confirmed by magnetic resonance imaging (MRI) or computed tomography (CT)
• Patients with a cognitive status sufficient to understand the study instructions (Mini-Mental State Assessment score ≥ 23)
• Patients with stable medical and psychological status
• Patients willing to participate in the study

Exclusion criteria

• Presence of hip pathologies that may lead to incorrect measurements in bone mineral density (advanced osteophytic coxarthrosis, heterotrophic ossification, internal fixator, etc.)
• Previous hip, lumbar vertebra fractures (osteoporotic compression fractures)
• History of multiple strokes
• History of concomitant neurological diseases other than stroke (Parkinson, multiple sclerosis, myopathy, etc.)
• History of diseases that may cause secondary osteoporosis (hypogonadism, primary hyperparathyroidism, thyrotoxicosis, malabsorption, etc.)