Osteoporosis and Haemophilia

PD Dr. Andreas Strauß

Status: Unknown

Conditions: Osteoporosis; Bone Mass; Haemophilia

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT04524481

2020-003072-41 (EudraCT Number)

NISOSTEO20200529

Details and patient eligibility

About

The aim of this study is to evaluate the prevalence of osteoporosis in adult patients with haemophilia.

Full description

The aim of this study is to evaluate the prevalence of osteoporosis in adult patients with haemophilia. Subsequently, the ascertained prevalence of osteoporosis in patients with haemophilia will be compared to the latest published data of osteoporosis in Germany. Furthermore, the impact of severity of haemophilia, comorbidities as well as the role of both physical activity and individual joint condition as influencing factors on the presence of osteoporosis will be analysed by this study.

Enrollment: 250 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (≥ 18 years of age) suffering from mild (FVIII or IX >5 %), moderate (FVIII or IX 1-5 %) or severe (FVIII or IX <1 %) haemophilia A or B
• Submitted written consent to participate in the study

Exclusion criteria

• Patients suffering from other bleeding diseases
• PWH without written consent
• PWH < 18 years of age
• Secondary osteoporosis

Trial design

250 participants in 3 patient groups

Patients with mild haemophilia A or B

Description:

(FVIII or IX \>5 %, ≥ 18 years' old)

Patients with moderate haemophilia A or B

Description:

(FVIII or IX 1-5 %, ≥ 18 years' old)

Patients with severe haemophilia A or B

Description:

(FVIII or IX \<1 %, ≥ 18 years' old)