Osteoradionecrosis and PENTOCLO Protocol: Retrospective Study (OPEN)

Regional University Hospital Center (CHRU)

Status: Completed

Conditions: Osteoradionecrosis of Jaw

Treatments: Drug: Pentoxifylline-Tocopherol-Clodronate

Study type: Observational

Funder types: Other

Identifiers

NCT04097847

OPEN (29BRC17.0115)

Details and patient eligibility

About

osteoradionecrosis (ORN) affects up to 30% of irradiated patients and can occur up to several decades after stopping treatment. Differents therapeutics exist but there is no consensus concerning the management of the maxillary ORN. The understanding of new pathological mechanisms opens the way to new therapeutic perspectives.

Enrollment: 96 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient over 18 being or having been treated by pentoclo combination for an osteoradionecrosis of the jaw

Exclusion criteria

• Tumoral recidivism
• Precocious stop of pentoclo