Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young Adults (FUBEO)

Universitaire Ziekenhuizen KU Leuven

Status: Unknown

Conditions: Osteosarcoma; Ewing Sarcoma

Treatments: Other: MRI

Study type: Observational

Funder types: Other

Identifiers

NCT01780779

S51516 (Other Identifier)

FUBEO

Details and patient eligibility

About

The purpose of the study was to investigate whether functional MRI imaging (diffusion weighted imaging) is useful for monitoring the therapeutic response of bone sarcomas in children and young adults. All patients will be scanned before, during and after chemotherapy. The findings on MRI will be correlated with histological finding after surgery.

Second purpose : to define apparent diffusion coefficient value of the bone sarcoma.

Third purpose : to try define prognostic factors, to investigate if there is a correlation between early treatment response and outcome.

Enrollment: 25 estimated patients

Sex: All

Ages: 6 to 30 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ewing or Osteosarcoma, proven by biopsy and histopathology
• all patients are treated by chemotherapy defined by EURAMOS and EURO-EWING protocol

Exclusion criteria

• Patients under the age of 6 years old
• patients with contra-indication for MR exam (pace-maker...)
• Patients with renal insufficiency
• Claustrophobia

Trial design

25 participants in 2 patient groups

Osteosarcoma

Description:

All patients with Osteosarcoma), proven by surgical biopsy and histopathology. All included patients will be treated by chemotherapy (EURAMOS protocol) An MRI will be performed before, during and post-treatment

Treatment:

Other: MRI

Ewing Sarcoma

Description:

All patients with proven diagnosis of Ewing sarcoma, proven by surgical biopsy and histopathology. All included patients will be treated by chemotherapy (EURO-EWING protocol) An MRI will be performed in all included patients before, during and after the chemotherapy

Treatment:

Other: MRI