Outbreak of Hemolytic Uremic Syndrome Linked to Escherichia Coli of Serotype O104:H4 (SHU O104 CUB)

University Hospital of Bordeaux

Status: Completed

Conditions: Escherichia Coli Infections; Hemolytic-uremic Syndrome

Treatments: Other: HUS standard coverage care (including in ICU)

Study type: Observational

Funder types: Other

Identifiers

NCT01406288

CHUBX2011/26

Details and patient eligibility

About

The Hemolytic Uremic Syndrome (HUS) in its typical form occurs after a food born infection with a shiga-toxin secreting bacteria, usually Escherichia coli of the O157H7 serotype. An outbreak of bloody diarrhea followed by HUS begun after a collective meal with 120 persons on June 8th, 2011 in Bègles, a city of Bordeaux urban area (CUB).

At least 9 patients, 8 adults and 1 child have been involved in this HUS outbreak, E. coli of the O104:H4 serotype being demonstrated in most patients. This outbreak is remarkable by its preponderance in adults and women, its aggressiveness with multiorgan involvement , i.e. the kidneys, brain, liver, pancreas, and skin.

Pathophysiology, prognosis, and treatment of typical HUS are poorly defined, particularly in adults who are usually not involved in typical E. coli O157H7 HUS.

The aim of the present study is to gain knowledge on these different aspects of the HUS, including response to therapy.

Enrollment: 9 patients

Sex: All

Ages: 2+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients with HUS concomitant to the outbreak linked to E. coli O104:H4

Exclusion criteria

• Patient not willing to participate or to sign informed consent

Trial design

9 participants in 1 patient group

HUS epidemy in Bordeaux, E. coli of the O104H4 serotype

Treatment:

Other: HUS standard coverage care (including in ICU)