Outcome of Patients With Primary Aldosteronism (PA_Outcome)

Changi General Hospital

Status: Unknown

Conditions: Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral); Primary Aldosteronism Due to Aldosterone Producing Adenoma; Mineralocorticoid Excess; Hypokalemia; Cardiovascular Morbidity; Chronic Renal Disease; Primary Aldosteronism; Adrenalectomy; Status; Mineralocorticoid Antagonists [Aldosterone Antagonists] Causing Adverse Effects in Therapeutic Use

Treatments: Procedure: Unilateral adrenalectomy in patients with unilateral disease

Study type: Observational

Funder types: Other

Identifiers

NCT04428827

PA_Outcome

Details and patient eligibility

About

Majority of patients with hypertension have primary hypertension (without an underlying cause). Primary aldosteronism (PA) is the most common cause of secondary hypertension, and can be found in 5-10% of patients locally. PA is caused by excessive release of a hormone (aldosterone) from the adrenal glands, which can be unilateral (one gland) or bilateral (both glands).

It has been shown that excess aldosterone has other harmful effects in addition to hypertension, such as directly affecting the heart, blood vessels, kidneys, leading to increased cardiovascular morbidity and mortality. This is supported by studies showing reversal of these effects after treatment for PA.

The investigators aim to assess the long-term cardiovascular, and renal outcomes of patients with PA, compared to patients with essential hypertension.

Enrollment: 600 estimated patients

Sex: All

Ages: 14 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with suspected primary aldosteronism

Exclusion criteria

• Nil

Trial design

600 participants in 2 patient groups

Surgery

Description:

Patients treated with surgery

Treatment:

Procedure: Unilateral adrenalectomy in patients with unilateral disease

Medications

Description:

Patients treated with mineralocorticoid antagonists or potassium sparing diuretics for primary aldosteronism