Outcome of Patients With Thoraco-abdominal Injury and Stress-induced Hyperglycemia or Diabetic Hyperglycemia

Chang Gung Medical Foundation

Status

Completed

Conditions

Hyperglycemia Stress

Hyperglycemia

Abdominal Injury

Thoracic Injury

Treatments

Other: Stress-induced hyperglycemia

Other: Non-diabetic normoglycemia

Other: Diabetic hyperglycemia

Other: Diabetic normoglycemia

Study type

Observational

Funder types

Other

Identifiers

NCT04058015

201900726B0

Details and patient eligibility

About

This study aimed to measure the effects of SIH and DH on the mortality outcomes of the adult patients with moderate to severe thoracoabdominal injury

Full description

Because the pathophysiologic response of the patients with a thoracoabdominal injury is different from those who had a traumatic brain injury, this study aimed to measure the effects of hyperglycemia induced by stress or by diabetes on the outcomes of patients with thoracoabdominal injuries in comparison with those who had non-diabetic normoglycemia (NDN). The primary study hypothesis stated that, following thoracoabdominal injuries, the patients with SIH had a worse outcome than patients with DH. The primary outcome was mortality rate of these patients.

Enrollment

802 patients

Sex

All

Ages

20 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

adult patients with moderate to severe thoracoabdominal injuries

Exclusion criteria

patients with a thoracic and abdominal abbreviated injury scale (AIS) < 3
patients who had polytrauma which was defined as there was additional AIS scores ≥ 3 points in other regions of the body
patients less than 20 years old
patients who had sustained a burn injury