Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care

Mahidol University

Status: Terminated

Conditions: Children; Wheat Allergy

Treatments: Other: wheat containing skin care products

Study type: Interventional

Funder types: Other

Identifiers

NCT04013763

038/2562(EC1)

Details and patient eligibility

About

Wheat allergy is increasing in Thailand. Some studies show that cutaneous exposure of allergen may cause allergy and there are many wheat containing skin care products that are over-the-counter. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to wheat and omega-5 gliadin in wheat allergy patients after stop using wheat containing skin care products.

Full description

All children in this study were sensitized to wheat. Each patient was clinically evaluated, with focus on wheat allergy by medical history, medical examination included skin status (suspected atopic dermatitis or not). Blood sample was taken for baseline determination of immunoglobulin E antibodies to wheat and to omega-5 gliadin. Transepidermal water loss was examined in case with atopic dermatitis. The primary outcome was the specific immunoglobulin E antibodies to wheat and omega-5 gliadin in case that stop using wheat containing skin care product and case that continue using products.

Enrollment: 7 patients

Sex: All

Ages: 1 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• children age 1 to 18 years
• History of IgE-mediated wheat allergy

Exclusion criteria

• Parents refused to sign the consent
• severe atopic dermatitis
• on oral immunothery
• severe IgE mediated reaction after using wheat containing skin care product

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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7 participants in 6 patient groups

Atopic dermatitis with stop using product

Experimental group

Description:

case wheat allergy with atopic dermatitis and stop using wheat containing skin care products

Treatment:

Other: wheat containing skin care products

Atopic dermatitis with containing using product

Experimental group

Description:

case wheat allergy with atopic dermatitis and continue using wheat containing skin care products

Treatment:

Other: wheat containing skin care products

Non atopic dermatitis with stop using product

Experimental group

Description:

case wheat allergy with normal skin and stop using wheat containing skin care products

Treatment:

Other: wheat containing skin care products

Non atopic dermatitis with continue using product

Experimental group

Description:

case wheat allergy with normal skin and continue using wheat containing skin care products

Treatment:

Other: wheat containing skin care products

Atopic dermatitis with no product use

No Intervention group

Description:

case wheat allergy who does not use wheat containing skin care products and has atopic dermatitis

Non atopic dermatitis with no product use

No Intervention group

Description:

case wheat allergy who does not use wheat containing skin care products and no atopic dermatitis