Outcome of Transarterial Chemo-embolization (TACE) in Hepatocellular Carcinoma Patients With Partial Portal Vein Thrombosis

Ain Shams University

Status and phase: Completed; Phase 4

Conditions: Hepatocellular Carcinoma (HCC)

Treatments: Procedure: transarterial chemoembolization versus the standard treatment with sorafinib

Study type: Interventional

Funder types: Other

Identifiers

NCT03007212

Hepatocellular Carcinoma

Details and patient eligibility

About

Portal vein tumor invasion (PVT) is a common complication in HCC. the studyb Aimed to assess the outcomes after TACE in patients with branch PVT regarding Child classification, radiological response and 1 year survival.

Full description

Thirty HCC patients (24 male, 6 females) Child A cirrhotics with branch PVT. Follow up was done at 1, 3, 6 and 12 months after first TACE. All patients underwent laboratory investigations including liver function tests to assess deterioration in liver functions, triphasic spiral CT to assess radiological response according to mRECIST criteria. Survival analysis was performed using Kaplan-Meier estimations.

Enrollment: 30 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with newly diagnosed HCC,
• Child class A and
• Portal vein branch tumoral thrombus (proved by imaging)
• written informed consent

Exclusion criteria

• patients with Child class B and C,
• main Portal vein thrombosis,
• previous management for HCC,
• Arterio-portal shunt
• refused to be enrolled

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

HCC patients with Pranch portal vein thrombosis

Experimental group

Description:

Thirty HCC patients (24 male, 6 females) Child A cirrhotics with branch PVT. Follow up was done at 1, 3, 6 and 12 months after first TACE. All patients underwent laboratory investigations including liver function tests to assess deterioration in liver functions, triphasic spiral CT to assess radiological response according to mRECIST criteria. Survival analysis was performed using Kaplan-Meier estimations.

Treatment:

Procedure: transarterial chemoembolization versus the standard treatment with sorafinib