Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy

National Taiwan University

Status: Terminated

Conditions: Other Complications of Esophagostomy

Treatments: Other: Intraoperative fluid therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01933451

201211078RIB

Details and patient eligibility

About

The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response and short-term outcome after esophagectomy and reconstruction.

Full description

Measurements: intraoperative Lung injury score, Lung water index, Pulmonary vascular Permeability Index Measurements: intraoperative and postoperative Plasma creatine, C reactive protein (CRP), lactate, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin-6 (IL-6), Interleukin-8 (IL-8)

Enrollment: 7 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing esophagectomy and reconstruction

Exclusion criteria

• ASA score >= 3, (American Society of Anesthesiologist physical status classification system)
• arrythmia, atrial fibrillation
• lung diseases, such as COPD (chronic obstructive pulmonary disease); lung function test showed moderate to severe ventilation defect
• plasma creatinine level above 1.5 mg/dl

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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7 participants in 2 patient groups

Restrictive intraoperative fluid therapy

Experimental group

Description:

To Keep intraoperative pulse pressure variation above 18%.

Treatment:

Other: Intraoperative fluid therapy

Liberal intraoperative fluid therapy

Other group

Description:

To keep intraoperative pulse pressure variation below 13%.

Treatment:

Other: Intraoperative fluid therapy