Outcome Study of Restrictive vs. Liberal Intraoperative Fluid Management Guided by PPV in Esophagectomy

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National Taiwan University

Status

Terminated

Conditions

Other Complications of Esophagostomy

Treatments

Other: Intraoperative fluid therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT01933451
201211078RIB

Details and patient eligibility

About

The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response and short-term outcome after esophagectomy and reconstruction.

Full description

Measurements: intraoperative Lung injury score, Lung water index, Pulmonary vascular Permeability Index Measurements: intraoperative and postoperative Plasma creatine, C reactive protein (CRP), lactate, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin-6 (IL-6), Interleukin-8 (IL-8)

Enrollment

7 patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients undergoing esophagectomy and reconstruction

Exclusion criteria

  • ASA score >= 3, (American Society of Anesthesiologist physical status classification system)
  • arrythmia, atrial fibrillation
  • lung diseases, such as COPD (chronic obstructive pulmonary disease); lung function test showed moderate to severe ventilation defect
  • plasma creatinine level above 1.5 mg/dl

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

7 participants in 2 patient groups

Restrictive intraoperative fluid therapy
Experimental group
Description:
To Keep intraoperative pulse pressure variation above 18%.
Treatment:
Other: Intraoperative fluid therapy
Liberal intraoperative fluid therapy
Other group
Description:
To keep intraoperative pulse pressure variation below 13%.
Treatment:
Other: Intraoperative fluid therapy

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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