Outcomes After Esophageal Cancer Surgery (FREGAT I)

University Hospital, Lille

Status

Completed

Conditions

Esophageal Disease

Esophageal Neoplasm

Treatments

Procedure: Esophagectomy

Study type

Observational

Funder types

Other

Identifiers

NCT01927016

2013_01

Details and patient eligibility

About

Background

Esophageal carcinoma is the sixth leading cause of cancer -related mortality and the eighth most common cancer worldwide
The incidence is increasing rapidly
The overall 5-year survival ranges from 15% to 25% in the literature and poor outcomes are related to diagnosis at advanced stages.
Surgery used to be the cornerstone of treatment of resectable esophageal cancer, but treatment of esophageal carcinoma remains challenging and need to be considered through a multimodal approach. However the modalities and the impact of this multimodal approach at a national level are unknown Primary objective: To identify predictors of recurrence after esophageal cancer surgery

Secondary objectives :

5-year recurrence free survival
5-year overall survival
Predictors of postoperative mortality and morbidity after surgery
Impact of pCR on recurrence and survival
Impact of neoadjuvant treatments on recurrence and survival
Impact of patient preconditioning (such as nutritional support, esophageal prosthesis, mini-invasive approach...) on outcomes

Methodology : European French-speaking retrospective multicentric study Inclusion criteria: All consecutive patients operated on, for a histologically proven carcinoma of the esophagus, the oesophago-gastric junction (Siewert type I and II), in surgical investigator centers between January 2000 and December 2010 Exclusion criteria: Siewert III type carcinoma of the oesophago-gastric junction , non surgical treatment of esophageal carcinoma Planned study period: The data will be collected over a 11-year period from January 2000 to December 2010. Follow up will be ascertained in May 2013.

Full description

Patients with an esophageal or junctional carcinoma (including SIewert type I and II) with surgical resection of the primary tumor inclusion date will be date of surgery all patients will be followed during 5 years after surgery or time of death

Enrollment

2,944 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

All consecutive patients operated on for a cancer of the esophagus , a Siewert I or II cancer of the esopgago-gastric junction in surgical oncology investigator centers
Surgery performed between 1st January 2000 and 31 December 2010

Exclusion criteria