Outcomes and Prognostic Factors in Hepatopancreatoduodenectomy (HPD_single)

Seoul National University

Status: Completed

Conditions: Bile Duct Cancer; Gall Bladder Cancer; Hepatectomy; Hepatopancreaticobiliary (HPB) Malignancy; Pancreatoduodenectomy

Treatments: Other: Hepatopancreatoduodenectomy

Study type: Observational

Funder types: Other

Identifiers

NCT06631352

2407-049-1551

Details and patient eligibility

About

1. In biliary tract malignancies, achieving a microscopically clear resection margin (R0) is considered the only treatment for a cure.
2. Hepatopancreatoduodenectomy(HPD) has been considered a surgical option for patients with extensive bile duct or gallbladder cancer to achieve an R0 resection.
3. The associated high morbidity and mortality rates have prevented HPD from becoming a standard surgical procedure worldwide.
4. Over the past few decades, the understanding of the bile duct anatomy has significantly improved, and many methods have been developed to assess liver function and future remnant liver volume.
5. We aimed to evaluate the short- and long-term outcomes of HPD and to assess risk factors associated with survival, early recurrence, and major complications to better evaluate the potential of the procedure as a standard treatment.

Enrollment: 50 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who received hepatopancreatoduodenectomy between January 2000 and December 2023.

Exclusion criteria

• Patients who had R2 resection

Trial design

50 participants in 2 patient groups

GB cancer

Description:

Patients who were diagnosed with gallbladder cancer and underwent the hepatopancreatoduodenectomy.

Treatment:

Other: Hepatopancreatoduodenectomy

CCA

Description:

Patients who were diagnosed with cholangiocarcinoma and underwent the hepatopancreatoduodenectomy.

Treatment:

Other: Hepatopancreatoduodenectomy