Outcomes Comparison Between Bone Resection and Subperiosteal Dissection for Specific Type of Soft Tissue Sarcoma

Zhejiang University

Status: Completed

Conditions: Soft Tissue Sarcoma; Cortical Contact

Treatments: Procedure: subperiosteal excision; Procedure: bone resection

Study type: Observational

Funder types: Other

Identifiers

NCT06317480

QH_2024

Details and patient eligibility

About

the purpose of this study is to assess whether bone resection for thigh soft tissue sarcoma with cortical involvement of the adjacent bone result in better local control and survival compared to sub-periosteal dissection. Investigators also aim to find out the prognostic factors for clinical outcomes in this group of patients.

Enrollment: 142 patients

Sex: All

Ages: 8 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients developed thigh soft tissue sarcoma, defined as lesion located below the plane of the lesser trochanter and above the plane of the femoral condyle.
2. received primary limb-salvage surgery at our center.
3. soft tissue sarcoma with only cortical contact of the adjacent bone based on preoperative imaging
4. minimum of 2-year follow up

Exclusion criteria

1. diagnosis was well differentiated liposarcoma
2. patients with metastatic disease at the time of presentation
3. soft tissue sarcoma displayed frank osseous invasion (eg. medullary canal invasion)

Trial design

142 participants in 2 patient groups

bone resection

Treatment:

Procedure: bone resection

subperiosteal excision

Treatment:

Procedure: subperiosteal excision