Outcomes of Concomitant Bypass Surgery in Septal Myectomy

Chinese Academy of Medical Sciences, Fuwai Hospital

Status

Completed

Conditions

Coronary Artery Disease

Myocardial Bridging

Hypertrophic Cardiomyopathy

Treatments

Procedure: CABG during myectomy

Study type

Observational

Funder types

Other

Identifiers

NCT06354413

2023-2261

Details and patient eligibility

About

To investigate clinical characteristics and survival outcomes of patients with obstructive hypertrophic cardiomyopathy who underwent concomitant coronary artery bypass grafting during septal myectomy.

Full description

Surgical septal myectomy (SM) is an effective approach for treating patients with drug-refractory obstructive hypertrophic cardiomyopathy (HCM).However, numerous patients with HCM exhibit concurrent ischemic heart disease, including atherosclerotic coronary artery disease (CAD) and myocardial bridging (MB). Although patients with HCM have been known to possess diminished coronary flow reserve,additional CAD can worsen myocardial ischemia, contributing to an unfavorable prognosis.MB, although infrequent, may affect diastolic heart perfusion, leading to angina and even sudden death.Current guidelines recommend revascularization for ischemic heart disease caused by CAD and MB.However, the impact of concomitant coronary revascularization during HCM management remains unclear. In this study, we analyzed the clinical characteristics and surgical scenarios of patients who underwent concomitant coronary artery bypass grafting (CABG) during ventricular SM and investigated their prognosis.

Patient clinical and survival data from 2009-2020 were retrospectively reviewed. The median follow-up period was 5.1 years. All-cause mortality was the primary endpoint.

Enrollment

320 patients

Sex

All

Ages

8 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria